抗菌:在植物系统中生产基于的新型治疗药物
Pragya Tiwari1, Yashdeep Srivastava2, Abhishek Sharma3
1Department of Biotechnology, Yeungnam University, Gyeongsan 38541, Gyeongbuk, Republic of Korea.
Life (Basel, Switzerland)
|September 28, 2023
概括
抗微生物 (AMP) 是对抗日益增长的抗生素耐药性的有希望的解决方案. 合成生物学和基于植物的生产方面的进展正在为高效的新型抗菌疗法铺平道路.
科学领域:
- 微生物学 微生物学
- 生物技术是生物技术.
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗生素耐药性是一个日益严重的全球健康和经济危机,由有限的发现平台和常规抗生素的滥用加剧.
- 生物来源,特别是抗微生物 (AMP),正在被探索为对抗耐药细菌菌株的重要替代品.
- 尽管取得了进展,但在充分理解和利用AMP用于治疗应用方面仍然存在知识差距.
研究的目的:
- 提供对抗微生物 (AMP) 作为对抗耐药病原体的战略的全面概述.
- 讨论AMP研究和药物发现的历史背景,最近的进展和未来的趋势.
- 突出植物系统在高效AMP生产中的潜力.
主要方法:
- 文献综述和关于AMP的当前研究的综合.
- 对抗微生物发现和开发的最新进展进行分析.
- 探索用于AMP生产的合成生物学和植物表达系统.
主要成果:
- 抗微生物 (AMP) 由于其独特的作用机制,显示出作为对抗耐药细菌的强效剂的巨大潜力.
- 了解AMP结构,功能和特征的进展正在增加.
- 基于植物的表达系统和合成生物学为AMP生产提供了新的,高效的方法.
结论:
- 抗微生物 (AMP) 代表了对抗抗生素耐药性的不断升级的威胁的关键治疗途径.
- 使用植物系统和合成生物学高效生产AMP标志着药物发现的重大进步.
- 需要进一步的研究来弥合现有的知识差距,并充分利用AMP的治疗潜力.
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