患有喘和CRSwNP治疗Dupilumab的患者的埃索诺菲尔电离蛋白变异
Andrea Giovanni Ledda1, Giulia Costanzo1, Giada Sambugaro1
1Department of Medical Sciences and Public Health, University of Cagliari, 09100 Cagliari, Italy.
Life (Basel, Switzerland)
|September 28, 2023
概括
对CRSwNP和喘的杜皮卢马布治疗最初增加了埃索诺菲尔和ECP,但这些生物标志物恢复到了基线. 杜皮卢马布改善了肺功能和喘控制,降低了IgE和FeNO水平.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 喘和带鼻息肉的慢性鼻炎 (CRSwNP) 通常具有相同的2型炎症内型.
- 2型炎症涉及IL-4,IL-13和IL-5等细胞因子,由ILC2和TH2细胞释放.
- 杜皮卢马布向IL-4受体α子单元,抑制IL-4和IL-13信号传递.
研究的目的:
- 调查dupilumab对CRSwNP和并发性喘患者的2型炎症生物标志物的影响.
- 评估乙氨基细胞计数 (EOS),乙氨基酸酸蛋白 (ECP),IgE和FeNO水平的变化.
- 评估dupilumab对控制喘和肺功能的影响.
主要方法:
- 在血清中使用免疫试验测量ECP,EOS和总IgE的纵向测量.
- 21名CRSwNP患者 (17名喘患者) 每两周服用300毫克杜皮卢马布.
- 评估部分呼出的氧化 (FeNO),喘控制测试 (ACT) 分数和FEV1.
主要成果:
- EOS和ECP显示过渡性增加,随后在10个月后恢复到基线水平.
- 在9个月后观察到FeNO和血清总IgE的显著下降.
- 在10个月后,ACT得分,FEV1%和绝对FEV1均有所改善.
结论:
- 在患有喘的CRSwNP患者中,杜皮卢马布治疗导致EOS和ECP暂时升高,随后正常化.
- 杜皮卢马布有效降低了2型炎症标志物,包括IgE和FeNO.
- 杜皮卢马布在控制喘和肺功能方面显著改善 (FEV1).
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