基于酸的水泥作为根末填充材料对抗Enterococcus faecalis的抗菌活性和持续有效性
Seong-Hee Moon1,2, Seong-Jin Shin2, Seunghan Oh1,2
1Institute of Biomaterials & Implant, College of Dentistry, Wonkwang University, 460 Iksan-daero, Iksan City 54538, Republic of Korea.
Materials (Basel, Switzerland)
|September 28, 2023
概括
预混合的可注射酸水泥 (EP) 显示出优异的抗菌活性和对Enterococcus faecalis的持续有效性,没有细胞毒性. 这使得它成为用于根端填充应用程序的有希望的材料.
科学领域:
- 生物材料科学 生物材料科学
- 牙周内科医院 牙周内科医院 牙周内科医院
- 微生物学 微生物学
背景情况:
- 酸水泥 (CSCs) 越来越多地用于根端填充,因为处理能力得到改善.
- 有效的根端填充材料不仅需要密封能力,还需要高生物相容性和抗菌性质.
- 菌 (Enterococcus faecalis) (E. faecalis) 是持续性内牙感染中常见的病原体,需要有效的抗菌剂.
研究的目的:
- 为了比较评估商业上可用的CSCs对E. faecalis的抗菌疗效和持续的抗菌疗效.
- 评估这些CSC在人类牙周带干细胞上的细胞毒性.
- 为了确定混合剂 (蒸水与赫西丁) 对CSC特性的影响.
主要方法:
- 商业上可用的CSCs (ProRoot,Endocem) 用蒸水 (DW) 或化 (CHX) 制备,包括预混合注射器类型 (EP).
- 使用直接接触方法评估了对E. faecalis的抗菌活性.
- 经过30天的储存后评估了抗菌可持续性,并使用细胞计数工具包-8测定细胞毒性.
主要成果:
- 预混合的Endocem (EP),使用DW的Endocem (EW) 和使用CHX的Endocem (EC) 显示出比使用CHX的ProRoot (PRC) 和使用DW的ProRoot (PRW) 显著更大的抗菌活性.
- EP在长达30天的时间内显示出最高的抗菌可持续性.
- EP没有对人类牙周带干细胞显著的细胞毒性.
结论:
- 预混合注射型EP表现出最有效的抗菌活性和持续的抗菌有效性.
- 由于其强大的抗菌作用和缺乏细胞毒性,EP是一种有前途的根末填充材料.
- 选择的CSC配方显著影响其抗菌性质和长期有效性.
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