乳腺癌老年妇女的预后工具:系统性审查
Sydney M Record1, Tori Chanenchuk1, Kendra M Parrish1
1Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
Medicina (Kaunas, Lithuania)
|September 28, 2023
概括
这项系统性审查确定了17个乳腺癌老年患者的预后模型,预测治疗反应,复发和死亡率. 虽然大多数模型都很有前途,但更广泛的临床应用需要外部验证.
科学领域:
- 在瘤学瘤学.
- 老年医学 老年医学
- 生物统计学 生物统计学
背景情况:
- 年长的成年人代表着乳腺癌患者日益增长和异质的人口.
- 现有的乳腺癌预后模型往往缺乏针对老年人群的具体验证.
- 最近需要进行系统审查,以评估为老年乳腺癌患者开发的工具.
研究的目的:
- 系统地审查针对乳腺癌老年患者开发或验证的预后模型.
- 评估这些预后工具的偏差风险和适用性.
主要方法:
- 在3个电子数据库中系统搜索2022年11月8日之前发表的研究.
- 包括针对老年乳腺癌患者基于临床病理因素开发或验证预后模型的研究.
- 使用PROBAST工具进行偏差风险和适用性评估.
主要成果:
- 确定了17个符合条件的文章,所有文章都展示了模型开发.
- 模型是在1996年至2022年之间开发的,主要是在美国,使用注册表数据.
- 在17个模型中,预测因素的中位数为7.
结论:
- 已经为老年乳腺癌患者开发了几种预后工具,预测不同的结果.
- 外部验证很少发生,但通常与内部验证结果一致.
- 大多数审查的模型显示,对老年乳腺癌患者的临床使用有希望,等待进一步验证.
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