非牛顿粘度对流体结构和符合蛇形微通道壁变形的影响:数值研究
Khemraj Deshmukh1, Kunal Mitra2, Arindam Bit1
1Department of Biomedical Engineering, National Institute of Technology, Raipur 492010, India.
Micromachines
|September 28, 2023
概括
了解微通道中的流体流动是再生毛细血管的关键. 这项研究表明,蛇形通道中的非牛顿粘度创造了可持续的剪切应力,改善了曲的细胞活力.
科学领域:
- 生物医学工程 生物医学工程
- 微流体学 微流体学
- 流体动力学 流体动力学
- 再生医学是一种再生医学.
背景情况:
- 流体粘度显著影响微通道流动力学,粘性阻力和剪切力是主要驱动因素.
- 毛细血管中的血液的风湿学会影响其功能,需要再生的毛细血管承受这些影响.
- 了解再生毛细血管中的培养介质流动物理对于在最佳剪切条件下促进血管生成至关重要.
研究的目的:
- 在S型 (S1) 和三角形 (S2) 蛇形毛细管模型中评估剪切应力分布,振荡式剪切指数 (OSI) 和相对剩余时间 (RRT).
- 在这些蛇形微通道模型中,研究培养介质风湿学对壁面应力参数的影响.
- 为了在生理流条件下比较非牛顿式与牛顿式流体模型中的流体物理和由此产生的切割应力.
主要方法:
- 利用S型 (S1) 和三角形 (S2) 蛇形模型来模拟毛细管道.
- 实施了一个非牛顿功率定律的公式来定义培养介质的修态粘度.
- 模拟鼻状和生理流动的启动,以模仿脉动的血液流动行为.
主要成果:
- 在S1和S2蛇形模型之间观察到切削应力分布的明显差异,S1的切削应力变化更高.
- 与牛顿流体相比,非牛顿粘度配方导致了与蛇形壁附近的更可持续的剪切应力.
- 发现,与直截面相比,蛇形通道的曲区域的细胞活力得到了改善.
结论:
- 文化媒介的风学显著影响蛇形微通道的壁面应力生成,非牛顿性质促进更稳定的剪切应力.
- 蛇形通道几何学调节流动条件,影响剪切应力分布,并可能提高特定区域的细胞活力.
- 这些发现对于设计有效的再生毛细血管,支持最佳血管生成和生理功能至关重要.
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