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相关实验视频

Updated: Jul 15, 2025

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology
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Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

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微流体液滴生成装置具有灵活的墙壁.

Sajad Yazdanparast1, Pouya Rezai1, Alidad Amirfazli1

  • 1Department of Mechanical Engineering, York University, Toronto, ON M3J 1P3, Canada.

Micromachines
|September 28, 2023
PubMed
概括

研究人员开发了一种灵活的微流体装置,用于精确控制滴滴大小. 这一创新使得从单一装置中获得更广泛的液滴大小,从而促进了药物发现和制造中的应用.

科学领域:

  • 微流体学 微流体学
  • 流体动力学 流体动力学
  • 生物医学工程 生物医学工程

背景情况:

  • 精确控制滴滴大小对于生物医学研究,药物发现,高通量查和乳液制造至关重要.
  • 目前的滴滴生成设备通常具有有限的滴滴大小范围,并且需要多个设置.

研究的目的:

  • 开发一个单一的共流微流体装置,可调节通道宽度,以灵活控制滴滴大小.
  • 调查通道宽度对滴滴生成模式和大小的影响.

主要方法:

  • 设计和制造了一种具有可调节的柔性墙壁的共流微流体装置.
  • 连续 (C) 阶段通道宽度变化以调节流速和粘性力.
  • 观察了滴滴生成模式 (滴滴和插头),并测量了不同通道宽度和流量条件的滴滴大小.

主要成果:

  • 调整通道宽度允许在单个设备内按需调节滴滴大小.
  • 根据通道宽度和低分散 (D) 阶段韦伯数,确定了滴水和插头两种模式.
  • 减少通道宽度,特别是在恒定的C相流速下,导致由于墙壁效应而导致更小的水滴,并增加了C相速度.
  • 滴滴大小范围达到了175913微米,远远大于现有的单个设备能力.
关键词:
同流的方法是同流的方法.液滴大小控制 控制液滴大小灵活的墙壁 灵活的墙壁微流体液滴生成 微流体液滴生成

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结论:

  • 开发的微流体装置提供了一个多功能平台,用于生成广泛的液滴大小.
  • 基于白金汉的Pi定理建立了一个经验模型来预测滴滴大小,并结合了通道尺寸和流量参数.