在输管患者的呼吸道微生物群和血微生物细胞外囊之间存在关联
Jinkyeong Park1, Seong Ji Woo2, Yoonki Hong3
1Department of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul 05278, Republic of Korea.
Microorganisms
|September 28, 2023
概括
血中的微生物衍生的细胞外囊泡 (mEVs) 与肺微生物组相比显示出不同的细菌组成. 在非肺炎患者中,肺和血mEV之间的更高相关性表明,mEV在免疫反应中起着有益的作用.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
背景情况:
- 细胞外囊泡 (EVs) 在人类疾病中的细胞和免疫功能中起着至关重要的作用.
- 微生物EV (mEV) 正因其在肺炎中的临床相关性而引起人们的注意.
- 肺部微生物组,微生物EV和肺炎的其他身体部位的微生物组之间的相互作用存在有限的研究.
研究的目的:
- 在机械通风患者中调查肺微生物组和血微生物衍生的EV (mEV) 之间的同时发生和相关性.
- 为了比较肺微生物组与肺炎和非肺炎病例中的血mEV之间的微生物相关性.
主要方法:
- 分析了来自60名机械通风患者的111个样本 (41名肺炎患者,19名非肺炎患者).
- 肺微生物组和血mEV之间的细菌组成的比较.
- 在不同患者群体中评估肺微生物组和血mEV之间的微生物相关性.
主要成果:
- 血mEV细菌组成与肺微生物组不同.
- 与肺炎患者相比,在非肺炎患者中观察到肺部微生物组和血mEV之间的相关性明显更高.
- 在非肺炎患者中,Acinetobacter和Lactobacillus属表现出高相关系数.
结论:
- 不同的细菌形状和不同的相关性突出显示了肺炎和非肺炎状态之间的微生物动态差异.
- 这些发现表明,微生物衍生的EVs可能在通过组分转移调节宿主肺部免疫反应方面发挥有益作用,特别是在没有肺炎的情况下.
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