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解读微生物组对类风湿性关节炎的影响
Donatella Coradduzza1, Marco Bo1, Antonella Congiargiu1
1Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Microorganisms
|September 28, 2023
概括
在类风湿性关节炎 (RA) 中,肠道微生物组发生变化,特定细菌增加或减少. 这些变化可能会导致RA患者的炎症和肠道屏障损伤.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病.
- 人们越来越认识到肠道微生物组在RA病变发生中的作用.
- 观察性研究提供了关于RA中宿主微生物相互作用的见解.
研究的目的:
- 批判性地审查和综合有关微生物组在RA中的病原性作用的数据.
- 探索RA患者肠道微生物群多样性和丰富性的变化.
- 评估RA和微生物组的观察性研究证据的质量.
主要方法:
- 在PubMed,Scopus和Web of Science (过去10年) 的系统文献搜索.
- 十项观察性研究的定性评估.
- 使用GRADE标准进行偏差风险评估.
- 使用16S rDNA测序分析便样本.
主要成果:
- 在RA患者和健康对照 (HCs) 之间肠道微生物组合的显著差异.
- 在RA中,细菌如*Faecalibacterium*和*Enterococcus*的丰度减少.
- 在RA中增加了包括*Prevotella copri*,*Collinsella*和*Klebsiella*在内的细菌的丰富性.
- 这些变化包括增加的*Prevotella copri*和*Lactobacillus*,以及减少的*Collinsella*.
结论:
- 与HC相比,RA患者的肠道微生物组组成在RA患者中发生了显著的变化.
- 假设这些微生物的转变会促进炎症并损害肠道屏障的完整性.
- 需要进一步的研究来证实微生物组变化和RA发展之间的因果关系.
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