亚利桑那州农村地区的Helicobacter pylori抗生素耐药率:基于分子的研究
Fernando P Monroy1,2, Heidi E Brown3, Claudia M Acevedo-Solis1
1Department of Biological Sciences, College of the Environment, Forestry and Natural Sciences, Northern Arizona University, 617 South Beaver Street, Flagstaff, AZ 86011, USA.
Microorganisms
|September 28, 2023
概括
杆菌 (H. pylori) 的抗生素耐药性是一个日益关注的问题,特别是在农村土著社区. 这项研究发现耐药性突变的高率,突出了针对性治疗策略的需要.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 遗传学 遗传学 是一个
背景情况:
- 杆菌 (H. pylori) 感染是胃癌的主要原因.
- 全球范围内,H. pylori的抗生素耐药性正在增加,这给治疗带来了挑战.
- 关于美国农村土著人口中H. pylori抗生素耐药性的数据有限.
研究的目的:
- 在亚利桑那州北部的美国印第安人患者中调查H. pylori中抗生素耐药性突变的患病率.
- 为了识别与克拉里胺和甲尼达抗性相关的特定突变.
主要方法:
- 从67名H.pylori阳性内镜患者的胃活检样本进行了测序.
- 分析的重点是23S核糖体RNA (23S) 和对氧不敏感的NADPH氧还原酶 (rdxA) 区域的耐药性突变.
- 检查患者病史和内镜检查结果的医疗记录.
主要成果:
- 在49名没有先前感染过H. pylori的个体中,38.8%患有克拉里素耐药突变 (T2182C最常见).
- 耐美特醇突变非常普遍 (93.9%),其中D95N和L62V是最常见的.
- 在抗性突变患病率上没有观察到基于性别的显著差异.
结论:
- 在这个农村土著人口中观察到H. pylori抗生素耐药性突变的高率.
- 这些发现强调了需要考虑耐药性概况来有效治疗H. pylori的必要性.
- 该研究强调了耐药性测试的重要性,特别是考虑到H. pylori的高流行率和低测试率.
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