延长血小板保质期的安全性分析,用澳大利亚的BACT/ALERT®和VIRTUO®进行大批量延迟采样
Anthea Cheng1, Anindita Das1,2,3, Khin Chaw1,4
1Donor and Product Safety Policy Unit, Australian Red Cross Lifeblood, West Melbourne, VIC 3003, Australia.
Microorganisms
|September 28, 2023
概括
使用BACT/ALERT VIRTUO和大容量延迟采样协议对血小板的细菌污染查显著改善了输血安全. 这种先进的方法确保没有报告输血传播的细菌感染病例.
科学领域:
- 血液学 血液学 血液学
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 输血传染性细菌感染 (TTBI) 是与输血相关的主要风险,特别是由于存储条件,与血小板成分有关.
- 澳大利亚红十字会的生命血液在2008年对所有血小板成分实施了细菌污染查 (BCS),以减轻TTBI风险.
研究的目的:
- 评估使用BACT/ALERT VIRTUO和大容量延迟采样 (LVDS) 方法对血小板组件进行更新的BCS协议的有效性.
- 评估新协议对减少浪费,改善血小板库存和提高输血安全的影响.
主要方法:
- 实施BACT/ALERT VIRTUO系统与LVDS协议用于血小板组件的常规BCS.
- 将血小板的保质期延长到7天.
- 细菌生长模式的分析,专注于对病原性与非病原性物种的检测时间.
主要成果:
- 更新的BCS协议,结合LVDS和VIRTUO,导致虚假阳性率降低,浪费减少,并改善了血小板库存管理.
- 早期检测了致病细菌,大多数细菌在化后24小时内生长.
- 在研究期间没有报告任何TTBI病例,这表明高安全性,即使是被诸如Cutibacterium物种等低致病性生物体污染的组件.
结论:
- 结合LVDS和BACT/ALERT VIRTUO,可通过早期检测细菌,显著提高血小板输血的安全性.
- 目前的协议非常有效,没有观察到TTBI病例.
- 超过五天的化培养瓶对于检测血小板组件中的细菌污染没有额外的好处.
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