血细菌DNA负载作为早期检测结肠直肠癌的潜在生物标志物:一个案例对照研究
Robertina Giacconi1, Rossella Donghia2, Graziana Arborea2
1Advanced Technology Center for Aging Research, IRCCS INRCA, Via Birarelli 8, 60121 Ancona, Italy.
Microorganisms
|September 28, 2023
概括
血中的细菌DNA升高可能表明结肠直肠癌 (CRC). 较高水平与CRC风险和较大的瘤大小相关,这表明癌症患者的细菌转移.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群在结直肠癌 (CRC) 的发展中起着至关重要的作用.
- 在血中检测细菌DNA为早期癌症诊断提供了潜在的非侵入性生物标志物.
研究的目的:
- 量化CRC患者与对照者的血细菌DNA.
- 调查血细菌DNA水平与CRC中的临床参数之间的相关性.
主要方法:
- 在50名CRC患者和40名健康对照患者的血细菌DNA负载的比较分析.
- 对年龄和性别进行调整的后勤回归分析,以评估CRC风险相关性.
- 细菌DNA水平与瘤质量之间的相关性分析.
主要成果:
- 与对照组相比,CRC组的血细菌DNA水平明显高于对照组.
- 血细菌DNA升高与CRC风险增加有很强的相关性 (OR = 1.02,p < 0.001).
- 瘤质量的减少与血细菌DNA的最高三位数有关.
结论:
- 患有CRC的个体表现出血细菌DNA的增加,支持从肠道转移细菌.
- 血细菌DNA负载是CRC风险和瘤负担的潜在指标.
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