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揭示了铜离子在氨基原蛋白聚合中的作用

Valentina Oliveri1

  • 1Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A Doria 6, 95125 Catania, Italy.

Molecules (Basel, Switzerland)
|September 28, 2023
PubMed
概括

铜的失调有助于粉样蛋白疾病,通过促进有毒蛋白质聚合和细胞损伤. 了解铜的理解 了解铜的理解

关键词:
这就是阿尔茨海默病的原因.神经基因 B 类的神经基因帕金森 帕金森症候群氨基化物 氨基化物铜铜 铜铜的铜.糖尿病 糖尿病患者 糖尿病患者错误折叠 错误折叠 错误折叠 错误折叠普里昂是什么意思?普里昂是什么意思?一个同核蛋白.知道的 知道的 知道的

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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