关于在非法粉末中快速查和结构识别胺类类似物质的质谱碎片化模式的研究
Yilei Fan1,2, Jianhong Gao3, Xianxin Chen3
1Key Laboratory of Drug Prevention and Control Technology of Zhejiang Province, Department of Criminal Science and Technology, Zhejiang Police College, Hangzhou 310053, China.
Molecules (Basel, Switzerland)
|September 28, 2023
概括
质谱检测揭示了胺类类似物有规律的碎片化模式,使得这些物质在被扣押的材料中能够快速识别. 这有助于打击与滥用相关的新出现的健康和社会问题.
科学领域:
- 法医化学 法医化学
- 分析化学 分析化学
- 质谱测量质量谱测量
背景情况:
- 胺类类似物是新出现的物质,导致严重的健康和社会问题.
- 这些类似物共享一个核心的2 - - 2 - 2 - 氨基基环黑色结构与修改.
- 了解它们的质谱碎片化对于识别至关重要.
研究的目的:
- 系统地研究八种胺类同类物质的质谱 (MS) 分裂路径.
- 为快速选胺类相似物建立特征性的碎片化模式.
- 在可疑的粉末样本中识别特定的胺类比物.
主要方法:
- 气色谱-四极点飞行时间质谱 (GC-QTOF/MS).
- 液体染色学-Q-轨道谱质谱/质谱 (LC-Q-轨道谱MS/MS) 在正电喷射电离模式下.
- 核磁共振 (NMR) 用于结构确认.
主要成果:
- 在电子电离质谱 (EI-MS) 模式下确定了特征性碎片化途径,包括α-裂变和基损失.
- 在电子喷射电离并列质谱 (ESI-MS/MS) 模式下确定了独特的碎片化途径,例如水损失和序列碎片损失.
- 成功地应用了MS碎片化模式,以快速选可疑粉末中的胺类同类物质,识别了2- ((Methylamino) -2- ((o-tolyl) 环-1-one.
结论:
- 凯胺类同类的MS碎片化模式中确定的规律性.
- 证明了MS的实用性,用于在扣押材料中快速选和识别胺类类似物.
- 为法医分析和对新出现的胺相关物质的控制提供了基础.
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