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印度基化合物作为SARS-CoV-2的潜在药物候选物

Adel S Girgis¹, Siva S Panda^2,3, Benson M Kariuki⁴

¹Department of Pesticide Chemistry, National Research Centre, Dokki, Giza 12622, Egypt.

Molecules (Basel, Switzerland)

|September 28, 2023

概括

本综述探讨了有希望的重定向药物,其中包括用于对抗SARS-CoV-2感染的印多异环. 印化合物和in silico方法为开发新的抗COVID-19疗法提供了潜力.

科学领域:

药用化学医学化学
药物发现药物发现药物发现
病毒学病毒学

背景情况:

由SARS-CoV-2病毒引起的COVID-19大流行仍然是全球健康问题.
尽管进行了广泛的研究,但对于COVID-19的有效治疗方法,特别是对于严重病例,仍然缺乏.
SARS-CoV-2 突变的出现需要持续开发抗病毒药物.

研究的目的:

审查含有印度异环支架的有希望的重用药物,用于抗SARS-CoV-2活性.
讨论天然和合成的英多尔衍生物与潜在的治疗效益对抗SARS-CoV-2.
探索计算机辅助药物设计在优化抗SARS-CoV-2候选药物的应用.

主要方法:

对重新使用的药物和含有英多尔的化合物的文献综述.
对抗SARS-CoV-2药物的现有研究进行分析.
讨论药物优化中的in silico方法.

主要成果:

印度类异环体代表了在具有多种生物活动的化合物中发现的多功能支架.
几种天然和合成的醇衍生物显示出作为抗SARS-CoV-2剂的前景.
计算机辅助药物设计可以加速化合物的识别和优化.

结论:

基于印的化合物是开发新型抗SARS-CoV-2疗法的有前途领域.
重新设计的药物和新型的醇衍生品需要进一步调查COVID-19治疗.
在 silico 研究是提高抗病毒药物发现的有效性有价值的工具.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.类化合物是一种类化合物.在的中.印度 (Indole) 是一种制剂.自然的自然的自然的自然的自然这是一种合成的合成物质.

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