制造可调整尺寸的PEG-PLGA微粒,用于控制药物释放应用
Paul Nana Kwame Sagoe1, Eduardo José Machado Velázquez2, Yohely Maria Espiritusanto1
1Department of Biomedical and Chemical Engineering, Bioinspired Syracuse: Institute for Material and Living System, Syracuse University, Syracuse, NY 13244, USA.
Molecules (Basel, Switzerland)
|September 28, 2023
概括
一种新的同轴流相分离方法可以精确控制聚乙烯甘 - 聚乳酸 - 同甘酸 (PEG-PLGA) 微粒大小和形态,以改进药物递送系统.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 聚合物微粒,特别是PEG-PLGA,是重要的药物载体.
- 现有的方法在精确的尺寸调整,统一性和可重复性方面扎.
- 挑战包括控制颗粒大小,形态,产量和药物载荷能力.
研究的目的:
- 开发一种可调节,单分散微粒合成的可扩展方法.
- 研究工艺参数对微粒子特性的影响.
- 优化微粒制造以提高药物加载和释放.
主要方法:
- 微粒子合成的同轴流相分离技术.
- 系统评估聚合物度,速,表面活性剂度和流量.
- 纳入光染料以模拟水友性和疏水性药物.
主要成果:
- 速和聚合物度显著影响颗粒大小和分布.
- 表面活性剂度是控制粒子形态学的关键.
- 实现了可调节的颗粒大小 (5-50μm),具有高单分散性和批量复制性.
- 证明了各种形态和度的可扩展性和可调性.
- 尽管聚合物度和体积的数量有序变化,但在配方中实现了可比的颗粒大小 (5-7μm).
- 聚合物数量影响药物加载,封装效率和释放动力学.
结论:
- 新的同轴流相分离方法可以精确控制PEG-PLGA微粒制造.
- 这种技术允许调整大小,改进单分散性和批次到批次的可重复性.
- 这些发现为制造含有药物的微粒提供了一个框架,这些微粒具有针对特定输送应用的定制性质.
相关概念视频
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
01:22Modified-Release Drug Delivery Systems: Rate-Programmed I
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...