带有添加的铁酸盐的磁铁体在脂质表面定,以增强DOX释放
Beatriz D Cardoso1,2,3,4, Diana E M Fernandes1,2, Carlos O Amorim5
1Physics Centre of Minho and Porto Universities (CF-UM-UP), Campus de Gualtar, 4710-057 Braga, Portugal.
Nanomaterials (Basel, Switzerland)
|September 28, 2023
概括
这项研究引入了用于向癌症药物输送的新型磁极体 (MLs). 这些ML有效封装多克索鲁比 (DOX),并使近红外激光诱导的高温和酸性条件触发的受控释放.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
背景情况:
- 纳米技术通过纳米载体提供先进的癌症治疗策略,用于向药物输送.
- 磁性纳米系统,特别是磁极体 (MLs),对药物封装,运输和控制释放具有前景.
- 开发新的磁纳米载体对于提高治疗疗效和最大限度地减少副作用至关重要.
研究的目的:
- 设计,开发和表征使用超偏磁纳米颗粒功能化的新型磁极体 (MLs).
- 评估这些MLs对光热过热和控制药物释放的潜力.
- 评估多克索鲁比 (DOX) 封装和释放在各种刺激下的效率.
主要方法:
- 合成二聚氨酸 (DMSA) 功能化的Ca0.25Mg0.75Fe2O4超偏磁纳米粒子.
- 纳米颗粒与DPPC/DSPC/CHEMS和DPPC/DSPC/CHEMS/DSPE-PEG脂质双层的合形成MLs.
- 在不同温度,pH值和近红外 (NIR) 激光照射下封装多克索鲁比 (DOX) 和药物释放研究.
主要成果:
- 在NIR激光照射下,DMSA功能化的纳米粒子呈现出立方形 (13.36nm) 和显著的温度增加.
- 磁脂体 (MLs) 已成功合成,其尺寸为153 ± 8nm (非PEGylated) 和136 ± 2nm (PEGylated).
- 实现了高DOX封装效率 (96-98%),在酸性pH (5.5) 和升温 (42°C) 时释放效率提高,并通过NIR激光刺激进一步放大.
结论:
- 开发出来的磁脂体显示出控制多克索鲁比释放的显著潜力,特别是在NIR激光刺激和酸性条件下.
- 这些MLs在生理环境中提供了持续和减少的药物释放特征 (pH 7.4).
- 这些发现突出了这些磁纳米载体的治疗承诺,通过光热过热和药物输送来向癌症治疗.
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