蒙古患者的潜伏性结核病感染,维生素D状态和COVID-19严重程度
Davaasambuu Ganmaa1,2, Tserendorj Chinbayar3, Polyna Khudaykov4
1Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Nutrients
|September 28, 2023
概括
活跃结核病 (TB) 和年龄较大增加了蒙古住院患者的COVID-19严重程度. COVID-19疫苗接种史和BCG痕提供了对严重疾病的保护.
科学领域:
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
- 公共卫生 公共卫生
背景情况:
- COVID-19 (冠状病毒疾病2019) 构成了全球健康的重大威胁.
- 了解严重COVID-19的风险因素对于患者管理和公共卫生策略至关重要.
- 结核病 (TB) 和维生素D缺乏是影响传染病结果的潜在共同因素.
研究的目的:
- 在蒙古的住院患者中识别COVID-19严重程度的风险因素.
- 调查血清维生素D水平和潜伏结核病感染在COVID-19严重性中的作用.
- 分析疾病并发症和治疗结果对COVID-19严重性的影响.
主要方法:
- 对蒙古270名COVID-19住院患者的人口,临床和实验室数据的回顾性分析.
- 评估COVID-19的严重程度分为轻度至中度,严重和危急.
- 统计分析以确定风险因素 (如维生素D,结核病,慢性肺炎,疫苗接种) 与COVID-19严重程度之间的关联.
主要成果:
- 活性结核病与严重或危急的COVID-19 (OR = 10.6) 有意义地相关.
- 年龄较大,男性性别,活跃结核病和COPD与COVID-19严重程度的增加有关.
- COVID-19疫苗接种史和BCG痕存在与疾病严重程度的降低有关.
- 严重的维生素D缺乏 (<10 ng/mL) 是常见的 (32%),但与疾病严重程度没有显著联系 (p = 0.65).
结论:
- 在这个蒙古人群中,活性结核病是严重COVID-19的主要风险因素.
- 疫苗接种状况和BCG痕可能会对严重的COVID-19提供保护.
- 需要进一步的研究来澄清维生素D在COVID-19结果中的作用.
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