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肌酸和抵抗训练:一种联合方法来减轻多克索鲁比诱导的心脏毒性
David Law1, Mitchel A Magrini1, Jacob A Siedlik1,2
1Department of Exercise Science and Pre-Health Professions, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA.
Nutrients
|September 28, 2023
概括
抵抗训练和肌酸补充剂可以在化疗期间保护心脏健康. 这项研究发现,这些干预措施,单独或组合,有助于减少多克索鲁比诱导的心脏毒性在老鼠.
科学领域:
- 心血管生理学心血管生理学
- 运动科学 运动科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 多克索鲁比 (DOX) 是一种重要的化疗药物,但会引起心脏毒性.
- 运动,特别是有氧运动,已知可以减轻DOX的副作用.
- 无氧运动和肌酸在DOX诱导的心脏毒性的作用还没有得到充分研究.
研究的目的:
- 调查肌酸 (CR) 和抵抗训练 (RT) 在预防DOX诱导的心脏毒性方面的潜力.
- 探索CR和RT在DOX治疗期间对心脏功能的联合影响.
主要方法:
- 雄性斯普拉格-道利大鼠接受了为期10周的抵抗训练 (RT) 或久坐 (SED) 活动.
- 组接受了盐水 (SAL) 或多克索鲁比辛 (DOX) 和肌酸 (CR) 或安慰剂.
- DOX每周服用4周,并通过心声扫描评估心脏功能.
主要成果:
- 与SED + DOX相比,DOX + CR,RT + DOX和RT + CR + DOX组显示左心室直径减少.
- 在RT+CR+DOX组,心脏质量明显高于SED+DOX组.
- RT和CR,单独和组合,证明了对DOX心脏毒性的保护作用.
结论:
- 抵抗训练和肌酸补充剂可以减轻DOX诱导的心脏毒性.
- 这些干预措施提供了一种潜在的成本有效的策略,以改善癌症患者的治疗结果.
- 需要进一步的研究来阐明DOX治疗期间肌酸的长期影响和临床影响.
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