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红醇可以抑制老化分子在老鼠牙组织和人类牙纤维细胞中的表达
Haruna Yokoi1,2, Masae Furukawa1, Jingshu Wang1
1Department of Oral Disease Research, Geroscience Research Center, National Center for Geriatrics and Gerontology, Obu 474-8511, Japan.
Nutrients
|September 28, 2023
概括
红醇是一种糖醇,可以通过减少牙周组织中的细胞衰老来预防与年龄相关的口腔疾病. 这项研究表明,红醇抑制老化标志物在老鼠和人类细胞.
科学领域:
- 口腔生物学 口腔生物学
- 老年学是一门学科.
- 生物化学 生物化学
背景情况:
- 口腔衰老与牙周病有关.
- 细胞衰老有助于衰老和组织功能障碍.
- 红醇已知具有抗脏性质.
研究的目的:
- 为了研究红醇对衰老的牙周组织和牙纤维细胞的影响.
- 为了确定红醇是否可以减轻口腔中与年龄相关的细胞衰老.
主要方法:
- 小鼠模型 (年轻的,老的,用红醇老化的) 和体外人类牙纤维细胞.
- 对与衰老相关的基因和蛋白质标记物的分析 (p16,p21,γH2AX,NF-κB p65,IL-1β,TNFα).
- 使用H2O2和脂多糖的老化诱导,然后进行红醇治疗.
主要成果:
- 年龄较大的小鼠在牙中表现出老化标志物 (p16,p21,γH2AX,IL-1β,TNFα,NF-κB p65) 的增加.
- 在老年小鼠中,乙醇的使用显著抑制了这些衰老标志物.
- 红醇减少了培养的人类牙纤维细胞中的衰老标志物,并挽救了pyruvate生产.
结论:
- 内红醇的使用可以预防与年龄相关的口腔粘膜疾病.
- 红醇显示出作为治疗口腔衰老和相关病理的治疗剂的潜力.
- 红醇对细胞衰老途径的影响需要进一步研究.
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