平衡和精神疾病:孟德尔的随机化研究
Miaomiao Jiang1, Weiheng Yan2, Xianjing Li1
1National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), NHC Key Laboratory of Mental Health, Peking University Sixth Hospital, Peking University Institute of Mental Health, Peking University, Beijing 100191, China.
Nutrients
|September 28, 2023
概括
这项研究揭示了精神疾病和平衡之间的因果关系,特别是在精神分裂症患者中显示出较低的维生素D水平. 对于患有心理健康状况的人来说,建议对维生素D进行监测.
科学领域:
- 营养精神病学 营养精神病学
- 代谢精神病学 代谢精神病学
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究表明,平衡与精神疾病之间存在联系.
- 这些关联的因果关系仍未得到证实.
- 关键的平衡激素包括,25-氧维生素D (25OHD),副甲状腺激素和FGF23.
研究的目的:
- 通过使用孟德尔随机化来研究平衡激素与九种精神疾病之间的因果关系.
- 评估精神疾病对平衡的影响.
- 评估25OHD水平在精神分裂症中的作用.
主要方法:
- 双向门德尔随机化 (MR) 分析.
- 逆方差加权 (IVW) 方法和 MR 施泰格因果关系测试.
- 灵敏度分析包括科克兰的Q测试,MR-Egger拦截,漏斗图和留出一个漏洞分析.
- 多变量MR (MVMR) 来调整像BMI和补充摄入量这样的混因素.
主要成果:
- 在精神分裂症 (SCZ) 和血清25OHD水平降低 (P=2.39 × 10−7) 之间发现了显著的因果关系.
- 这种关联在MVMR分析中仍然存在,即使经过对混因素进行调整.
- 自闭症谱系障碍和双相情感障碍显示名义上的关联与较低的25OHD.
结论:
- 证据支持精神疾病对平衡的因果关系.
- 降低25OHD水平是精神分裂症的潜在因果因素.
- 对于精神病患者,建议对25OHD水平进行临床监测.
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