乳清蛋白补充剂对老年人炎症标志物度的影响
Samuel Adler1, Wyatt Olsen1, Bryna Rackerby1
1Department of Food Science & Technology, Oregon State University, Corvallis, OR 97331, USA.
Nutrients
|September 28, 2023
概括
在老年人中补充乳清蛋白分离剂并没有显著改变大多数炎症标志物. 观察到血清IL-13和便中乳酸的某些变化,但研究的低功率限制了对乳清蛋白的结论.
科学领域:
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
- 老年学是指老年学的学科.
背景情况:
- 乳清蛋白分离物 (WPI) 已知具有免疫调节作用.
- 关于WPI对健康成年人炎症标志物的广泛影响的研究有限.
- 调查WPI对老年人炎症的影响对于了解其健康益处至关重要.
研究的目的:
- 研究每日WPI补充剂对健康老年人血清和便炎症标志物的影响.
- 评估WPI对广泛的细胞因子和特定的炎症标记物 (calprotectin,乳酪蛋白) 的调节.
- 为了确定WPI补充剂是否会改变老龄化人口的炎症概况.
主要方法:
- 14名健康的老年人 (平均年龄59岁) 每天接受35克WPI,持续3周.
- 血清细胞因子 (IFN-γ,IL-1β,IL-1RA,IL-2,IL-3,IL-4,IL-5,IL-6,IL-7,IL-8,IL-9,IL-10,IL-12p70,IL-13,IL-17A,TNF-α) 使用多重测定进行测量.
- 用ELISA分析便样本以检测calprotectin和lactoferrin的存在.
主要成果:
- 观察到高个体间的变异性,许多细胞因子度低于量化限值.
- 与基线相比,在洗阶段观察到血清IL-12p70的减少.
- 血清IL-13和便中乳酸在干预/洗阶段显著减少,尽管研究功率低 (35%).
结论:
- 在健康的老年人中,WPI补充剂没有显著改变大多数测量的炎症标志物.
- 血清IL-13和便中的乳酸铁素等特定标记物的适度变化可能会发生.
- 由于参与者数量很少,因此无法就WPI对这一群体炎症的影响得出明确结论.
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