胃肠道微生物组在肝脏疾病中的作用
Nicholas Shalaby1, Dorit Samocha-Bonet1,2, Nadeem O Kaakoush3
1School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, St Vincent's Healthcare Campus, Darlinghurst, NSW 2010, Australia.
Pathogens (Basel, Switzerland)
|September 28, 2023
概括
肝脏疾病每年导致数百万人的死亡. 准肠道微生物组提供了一种新的治疗方法来对抗肝纤维化和疾病进展.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 微生物组研究 微生物组研究
- 胃肠病学 胃肠病学
背景情况:
- 肝病是全球重要的健康问题,每年导致数百万人死亡,原因包括酒精,代谢功能障碍和病毒感染等.
- 目前的治疗方法侧重于管理潜在原因,因为目前还没有特定的抗纤维菌疗法可以逆转肝损伤和纤维化.
- 肝脏和胃肠道之间存在双向通信,受微生物代谢物如短链脂肪酸 (SCFA) 和二次胆汁酸的影响.
研究的目的:
- 审查当前对肝纤维化和肝脏疾病的理解.
- 探索肝脏和胃肠道微生物组之间的复杂联系.
- 确定潜在的治疗目标和减轻肝病进展的策略.
主要方法:
- 本综述综合了关于肝病,肝纤维化和肠道微生物组的现有研究.
- 它检查了微生物代谢物在肝肠轴通信中的作用.
- 该审查确定了基于微生物组相互作用的潜在治疗途径.
主要成果:
- 肝病的进展包括纤维化和肝硬化,治疗选择有限.
- 肠道微生物组及其代谢物 (SCFA,二次胆汁酸) 在肝脏健康中起着至关重要的作用.
- 失生症和改变的代谢物概况与肝脏疾病的发病有关.
结论:
- 肝脏和肠道微生物群之间的相互作用为新的治疗干预提供了一个有希望的领域.
- 调节微生物组及其代谢物可能为减轻肝病和纤维化提供策略.
- 对这些相互作用的进一步研究可能会导致肝脏疾病的新疗法.
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