由AMPC产生的肠杆菌引起的血流感染:风险因素和治疗结果
Mladen Pospišil1, Haris Car2, Vesna Elveđi-Gašparović3,4
1Krapina-Zagorje County Community Health Centre, 49245 Stubica, Croatia.
Pathogens (Basel, Switzerland)
|September 28, 2023
概括
产生AmpC的肠杆菌的血液感染是严重的. 这项研究发现并发症或手术与AmpC耐药性之间没有联系,但观察到高抗生素耐药率.
科学领域:
- 临床微生物学 临床微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 由AMPC产生的肠杆菌引起的血液感染 (BSI) 是一个重大的临床挑战.
- 有效的治疗对于预防严重后果至关重要.
研究的目的:
- 调查患者的并发病,手术史和AmpC产生的肠杆菌耐药性决定因子在BSI中的关联.
- 确定抗生素耐药性模式和治疗结果.
主要方法:
- 对患者数据的回顾性分析,重点关注并发病症和手术史.
- 产生AmpC的Enterobacterales分离物的表型和基因型特征.
- 对抗生素耐药性概况的评估,包括AmpC过度生产,ESBL和卡巴酶生产.
- 对治疗结果和死亡率的评估.
主要成果:
- 在 AMPC 生产的耐药和易受 AMPC 生产的肠道细菌分离物之间,并没有发现并发症或先前手术的显著差异.
- 总体而言,34.52%的分离物表现出耐药性 (AmpC过度生成,ESBL或卡巴酶).
- 在 *Providencia* spp. 中发现了对扩展谱头素的高耐药率. 和 *K.空气生成物*. 碳酶的产生最频繁地发生在 *Providencia* spp. 中.
结论:
- 并发症和手术史似乎与AMPC产生的肠杆菌BSI的特定耐药性机制无关.
- 产生AMpC的大量肠杆菌分离物表现出多种药物耐药性,这构成了治疗挑战.
- 越来越多的抗生素耐药性需要开发新的治疗策略.
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