是时候治疗作为预防慢性乙型肝炎吗?
Jose A Perez-Molina1,2,3,4, Marta Rosas Cancio-Suárez2,4,5, Santiago Moreno2,3,4,5
1National Reference Centre for Tropical Diseases, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
Pathogens (Basel, Switzerland)
|September 28, 2023
概括
乙型肝炎影响全球数百万人,尽管有疫苗和治疗方法,但新的感染和慢性病例仍在持续. 扩大治疗机会,特别是对于孕妇和慢性感染者来说,对于制传播和打击大流行病至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 乙型肝炎病毒 (HBV) 感染仍然是一个重大的全球健康挑战,导致高发病率和死亡率.
- 尽管有有效的疫苗和抗病毒药物,但大约有2.96亿人患有慢性HBV,每年有150万新感染者.
- 目前的治疗指南复杂,并排除了诸如孕妇和许多慢性感染个体等关键人群,可能会延续传播.
研究的目的:
- 突出目前乙型肝炎治疗指南的局限性.
- 倡导扩大治疗指示以控制HBV传播.
- 强调治疗作为公共卫生干预措施的作用,以实现2030年消除目标.
主要方法:
- 对目前关于乙型肝炎流行率和发病率的流行病学数据的审查.
- 分析现有的HBV治疗指南及其局限性.
- 讨论扩大治疗机会对公共卫生的影响.
主要成果:
- 核酸治疗有效控制HBV复制,改善预后,并防止母婴传播.
- 目前的指导方针未能涵盖重要的患者群体,包括孕妇和许多慢性感染者.
- 这些缺乏服务的人群具有可检测的HBV病毒载量,有助于持续的传播.
结论:
- 扩大和简化乙型肝炎治疗的指示对于控制疫情至关重要.
- 治疗更多的人,包括孕妇,可以预防传播,并减少全球HBV的负担.
- 实施治疗作为公共卫生战略对于实现联合国2030年HBV消除目标至关重要.
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