甲状腺上方注射:一种针对药物向的新方法
Kevin Y Wu1, Jamie K Fujioka2, Tara Gholamian3
1Department of Surgery, Division of Ophthalmology, University of Sherbrooke, Sherbrooke, QC J1G 2E8, Canada.
Pharmaceuticals (Basel, Switzerland)
|September 28, 2023
概括
超冠状腺注射为后部眼部疾病提供了一种新的向药物递送方法,与传统治疗相比,提高了生物可用性和减少了副作用.
科学领域:
- 眼科医生 眼科 眼科
- 药物输送系统 药物输送系统
- 视网膜疾病 视网膜疾病
背景情况:
- 治疗后部和视网膜疾病是具有挑战性的,因为眼障碍限制了药物输送.
- 目前的治疗方法,如眼滴和视内注射,往往需要频繁的剂量,并可能导致副作用.
研究的目的:
- 审查关于后部部位疾病的上注射的临床前和临床研究.
- 突出这一新型药物输送途径的潜力和局限性.
主要方法:
- 2019年至2023年间发表的临床前和临床研究的文献综述.
- 专注于研究研究suprachoroidal注射以向药物输送到眼睛后部的研究.
主要成果:
- 超冠状腺注射为后段提供有针对性的输送,提供更高的药物度,增加生物可用性和延长作用.
- 这种方法可以最大限度地减少与皮质类固醇相关的不良事件,如白内障和眼内压力升高.
结论:
- 甲状腺上方注射显示出治疗后部部位疾病的巨大潜力.
- 需要进一步的研究来克服技术,技巧,成本和可访问性方面的挑战,以便广泛采用.
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