通过化沉积模型开发双叶片,作为持续释放药物输送系统
Andrea Gabriela Crișan1, Alina Porfire1, Sonia Iurian1
1Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 41 Victor Babeș Street, 400012 Cluj-Napoca, Romania.
Pharmaceuticals (Basel, Switzerland)
|September 28, 2023
概括
这项研究使用热挤出和化沉积建模 (HME-FDM-3DP) 开发了3D打印的二甲片. 创新的设计确保了药物的立即和持续释放,从而增强了治疗效果.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 个性化剂型正随着3D打印技术的发展而发展,如沉积建模 (FDM) 和热挤出 (HME).
- 控制药物释放概况对于3D打印药物的有效性和安全性至关重要.
- 狄克洛菲纳克是一种广泛使用的非类固醇抗炎药物.
研究的目的:
- 开发3D打印的药片,用于持续释放二甲.
- 为了实现双释放配置文件:立即释放以获得快速效果,持续释放以获得长期作用.
- 探索使用聚乙烯醇作为两种释放型的多功能聚合物矩阵.
主要方法:
- 使用热挤出 (HME) 和化沉积建模 (FDM) 进行3D打印.
- 设计了特定的药片结构:蜂用于立即释放和充满结构用于持续释放.
- 研究聚乙醇 (PVA) 作为药物配方的聚合物矩阵.
主要成果:
- 成功制备3D打印的片剂,具有二重释放的二甲.
- 证明了从单一剂型中实现快速和缓慢的药物释放的可行性.
- 展示了聚乙烯醇作为多面矩阵材料的潜力,简化了配方.
结论:
- HME-FDM-3DP技术提供了一个可行的方法,用于创建个性化剂型,并量身定制的药物释放.
- 开发的配方和设计策略能够精确控制二二的释放动力学.
- 这项研究有助于推进HME-FDM-3DP作为制药制造方法的发展.
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