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Updated: Jul 15, 2025

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在子,老鼠和人类中开发一个基于生理学的尼托福兰的药动力学模型

Raju Prasad Sharma1, Elsje J Burgers1, Joost B Beltman1

  • 1Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

Pharmaceutics
|September 28, 2023
PubMed
概括

尼托福兰 (NFT) 可以引起肝脏毒性,特别是在功能受损的患者中. 一个新的生理学基础的药理动力学 (PBPK) 模型预测这些人更高的NFT肝脏暴露,增加DILI风险.

关键词:
药物诱导的肝损伤是药物诱导的酸黄胺是一种酸黄胺.基于生理学的药物动力学模型.功能不良 功能不良

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