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针对性纳米颗粒的创新设计:用于增强癌症治疗的聚合物-药物联合体

Varaporn Buraphacheep Junyaprasert¹, Parichart Thummarati¹

¹Department of Pharmacy, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayutthaya, Rajathavee, Bangkok 10400, Thailand.

|September 28, 2023

概括

聚合物 - 药物合物 (PDC) 通过将聚合物和药物结合起来,改善癌症治疗,以获得更好的输送效果和减少副作用. 本综述详细介绍了聚合物类型,结合方法和向配体,以提高癌症治疗的有效性和安全性.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
在瘤学瘤学.

背景情况:

聚合物-药物合物 (PDCs) 整合了聚合物和药物的好处,以改善癌症治疗.
PDCs提供增强的药理动力学,可控释放和瘤特异性输送.

研究的目的:

为癌症治疗PDCs的最新进展提供全面的回顾.
讨论聚合物选择,结合策略和向连接体,以优化PDC性能.

主要方法:

对合成聚合物 (如PCL,TPGS,PEG) 和天然聚合物 (如HA) 的审查.
探索结合技术,包括稳定链接的共价键.
讨论瘤向配体 (例如抗体,,叶酸) 的选择性药物输送.

主要成果:

聚合物选择影响稳定性,生物相容性和药物释放动力学.
联联确保了受控释放,并最大限度地减少了药物过早脱落.
增强的透性和保留 (EPR) 效应促进瘤积累,提高疗效和降低毒性.
向配体增强选择性,减少非向效应,改善治疗结果.

结论:

PDCs代表了促进癌症治疗的多功能和有效策略.
在PDC中聚合物和药物的组合导致了优异的药物输送,受控释放和向治疗.
对PDC的进一步研究为开发个性化癌症治疗选择提供了显著的潜力.

关键词:

在 EPR 效应中,EPR 效应是:积极的目标化是积极的目标化.癌症治疗疗法癌症治疗被动准是一种被动准.聚合物药物合物有针对性的纳米粒子.

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