相关实验视频

Updated: Jul 15, 2025

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

喷雾干燥的可吸入微粒组合雷姆迪西维尔和埃布塞伦,用于对抗SARS-CoV-2感染

Tushar Saha¹, Shubhra Sinha², Rhodri Harfoot²

¹School of Pharmacy, University of Otago, Dunedin 9054, New Zealand.

|September 28, 2023

概括

研究人员开发了一种可吸入的干粉,结合了remdesivir和ebselen,用于COVID-19治疗. 这种组合疗法显示出增强的疗效和低细胞毒性,为呼吸道病毒性疾病提供了一个有前途的新策略.

科学领域:

制药科学制药科学
药物输送系统药物输送系统
病毒学病毒学

背景情况:

开发针对2019年新冠病毒病 (COVID-19) 和其他病毒性呼吸道感染的有效治疗方法仍然是优先事项.
吸入疗法对于像SARS-CoV-2这样的呼吸道病毒是合乎逻辑的,向主要感染部位.
虽然单一治疗一直是标准,但药物组合在其他病毒性疾病中表现出更高的疗效.

研究的目的:

开发和描述一种可吸入的干粉配方,将雷梅西维尔和埃布塞伦结合起来,用于潜在的COVID-19治疗.
评估联合药物配方的气溶化特性,细胞毒性和抗病毒活性.

主要方法:

使用喷雾干燥技术,制造了雷梅西维尔和埃布塞伦的干粉配方.
添加L-氨酸作为一种气溶增强剂.
评估了颗粒大小,发射剂量 (ED),细颗粒分数 (FPF),细胞毒性 (CC50) 和抗SARS-CoV-2活性 (EC50).

主要成果:

成功制备了具有适合吸入颗粒大小 (1-3μm) 的球形晶体干粉.
氨酸显著改善了气溶化,使ED增加到>86%和FPF增加到>67%.
组合配方表现出最小的细胞毒性 (CC50 > 100μM),并保留了强大的抗SARS-CoV-2活性 (EC50 2.77至18.64μM).

结论:

通过喷雾干燥成功开发了一种可吸入的remdesivir和ebselen干粉配方.
该配方表现出有利的物理化学特性,用L-氨酸增强了气溶化,并保持了低细胞毒性的抗病毒疗效.
需要进一步的体内研究来验证这种组合疗法的治疗潜力,以防止SARS-CoV-2在呼吸道中的复制.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.干燥粉是干燥粉的方法之一.这是一个很棒的节日. ebselenelen 雷梅西维尔 (remdesivir) 是一种药物.有协同作用的协同作用.

更多相关视频

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

相关概念视频

Inhaled Medications

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...

Combined Effects of Drugs: Synergism

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...