纳米颗粒 (SeNPs) 对潜在的致病性口腔微生物的抗菌活性:一个范围审查
Eulàlia Sans-Serramitjana1, Macarena Obreque2, Fernanda Muñoz2
1Center of Plant, Soil Interaction and Natural Resources Biotechnology, Scientific and Biotechnological Bioresource Nucleus (BIOREN-UFRO), Universidad de La Frontera, Temuco 4811230, Chile.
Pharmaceutics
|September 28, 2023
概括
纳米颗粒 (SeNPs) 是抗生素的替代品,可用于对抗由细菌和真菌引起的口腔感染. 需要进一步的研究来证实它们在临床环境中的有效性.
科学领域:
- 纳米技术纳米技术
- 微生物学 微生物学
- 口腔健康 口腔健康
背景情况:
- 生物膜导致普遍存在的口腔感染,如牙和牙周病.
- 抗生素耐药性需要新的抗菌剂.
- 纳米粒子 (SeNPs) 正在探索它们的抗菌潜力.
研究的目的:
- 综合现有关于SeNPs对口腔病原体有效性的研究.
- 评估SeNPs对浮游生物和生物膜形式微生物的影响.
- 在体外评估SeNP的安全性和毒性.
主要方法:
- 在 MEDLINE,Embase,Scopus 和 Lilacs 数据库进行系统的文献搜索,截至 2022 年 5 月.
- 包括评估SeNPs抗菌活性和副作用的体外研究.
- 两个研究人员独立选择和提取数据,然后进行定性合成.
主要成果:
- 综述中包括了22篇文章.
- SeNPs对关键的口腔病原体具有显著的抗菌疗效,包括*C. albicans*,*S. mutans*,*E. faecalis*和*P. gingivalis*.
- 研究报告了有效的抗氧化活性和与SeNPs相关的有限毒性.
结论:
- 对于口腔病原体来说,SeNPs表现出有希望的抗微生物和抗氧化特性.
- 进一步的ex vivo和in vivo研究对于验证SeNPs作为安全有效的替代治疗方法至关重要.
- 对于未来的研究,需要对SeNPs的特性和实验条件进行标准化的报告.
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