相关实验视频

Updated: Jul 15, 2025

Double Emulsion Generation Using a Polydimethylsiloxane PDMS Co-axial Flow Focus Device

Double Emulsion Generation Using a Polydimethylsiloxane PDMS Co-axial Flow Focus Device

Published on: December 25, 2015

双螺丝融化颗粒化:一种单步方法,用于开发脂性药物的自我乳化药物输送系统

Dinesh Nyavanandi¹, Preethi Mandati¹, Sagar Narala¹

¹Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, Oxford, MS 38677, USA.

|September 28, 2023

概括

这项研究通过双螺旋化颗粒化 (TSMG) 提高了使用自乳化药物递送系统 (SEDDS) 的布洛芬溶解度. 固体SEDDS (S-SEDDS) 片显示药物释放和稳定性得到改善,证明了TSMGG.

科学领域:

制药技术制药技术制药技术
药物输送系统药物输送系统
材料科学材料科学材料科学

背景情况:

像布洛芬这样的溶解不良的药物会带来生物可用性挑战.
自乳化药物输送系统 (SEDDS) 是有效的提高药物的溶解性.
固体SEDDS (S-SEDDS) 的传统方法可能是复杂和耗时的.

研究的目的:

使用双螺旋融颗粒化 (TSMG) 方法开发稳定的S-SEDDS配方.
评估开发的S-SEDDS片的物理化学特性和稳定性.
调查TSMG作为S-SEDDS连续制造工艺的潜力.

主要方法:

用于液体SEDDS (L-SEDDS) 配方的辅助剂 (Gelucire®,Transcutol® HP) 的选.
使用不同油度和表面活性剂/辅助表面活性剂比率的L-SEDDS的开发.
使用吸附剂载体将L-SEDDS转换为S-SEDDS,然后通过TSMG通过片剂 (T-SEDDS) 进行.
使用差分扫描热量计 (DSC) 和粉末X射线衍射 (PXRD) 进行S-SEDDS的表征.
评估乳液球体大小,药物释放,流动性质和药片稳定性.

主要成果:

优化的L-SEDDS配方产生了稳定的乳液,球体大小小小于20nm.
与纯易布洛芬相比,S-SEDDS表现出增强的药物释放概况和改善的流动特性.
布洛芬在S-SEDDS中的无形状态被DSC和PXRD证实.
在加速和长期储存条件下,T-SEDDS药片在六个月后表现出良好的稳定性.
在一个单一的连续步骤中,TSMG成功生产了均的S-SEDDS配方.

结论:

TSMG方法是生产稳定的S-SEDDS平板电脑的可行和高效方法.
开发的S-SEDDS配方显著改善了易布洛芬的溶解性和溶解特性.
这种连续的制造过程为医药生产提供了一个有前途的替代品,即增强的药物输送系统.

关键词:

球体大小球体大小液体 SEDDS 是一个流动的 SEDDS.多分散性指数 (polydispersity index) 是一个多分散性指数.自体乳化药物递送系统是自体乳化药物递送系统.固体 SEDDS 是一个固体 SEDDS 双螺丝融化颗粒化

更多相关视频

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

相关概念视频

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...