相关实验视频

Updated: Jul 15, 2025

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

Published on: May 10, 2018

赫西丁-银纳米粒子结合导致抗菌协同作用,但增强了细胞毒性

Nadezhda Ivanova¹, Neli Ermenlieva², Lora Simeonova³

¹Department of Pharmaceutical Technologies, Faculty of Pharmacy, Medical University of Varna, 9000 Varna, Bulgaria.

|September 28, 2023

概括

这项研究创造了赫西丁-银纳米颗粒合物 (SN-Cx),显示出对细菌和真菌的增强抗微生物活性. 这些新型结合物表现出强化和协同作用,提供了一个有前途的新型抗菌剂.

科学领域:

纳米技术纳米技术
微生物学微生物学
材料科学材料科学材料科学

背景情况:

抗菌素耐药性需要新的治疗策略.
银纳米粒子 (SN) 具有广泛的抗微生物特性.
赫西丁 (Cx) 是一种广泛使用的消毒剂.

研究的目的:

合成和表征赫西丁-银纳米粒子结合物 (SN-Cx).
评估SN-Cx对流感A,黄金葡萄球菌,大肠杆菌和白菌的协同抗菌潜力.
为了评估合成的结合物的细胞毒性.

主要方法:

绿茶提取物减少用于SN合成.
使用UV-Vis,FTIR,DLS,XRD和TEM进行表征.
通过MIC确定进行抗菌活性测试.
对MDCK,BJ和A549细胞系的细胞毒性评估.

主要成果:

产生了负泽塔电位 (ζ = -50.01) 和92.34nm的水力动力直径的稳定SN.
通过光谱数据和正泽塔电位 (ζ = +44.59) 证实了Cx与SN的成功结合.
SN-Cx对S. aureus和C. albicans表现出强化作用,以及对大肠杆菌的协同作用.
虽然SN表现出病毒杀伤性和低毒性,但Cx在结合后仍然保持了细胞毒性.

结论:

赫西丁-银纳米颗粒结合物代表了一种具有广泛活性的强有力的抗菌剂.
对大肠杆菌的协同效应和对黄金杆菌和白杆菌的强化突出了治疗潜力.
进一步的体外和体内研究是有必要的,以探索SN-Cx的治疗应用.

关键词:

在Camellia sinensis中,有甲基因.抗微生物药物的协同作用抗病毒活动的抗病毒活性.氧化的含量是多少复杂化的复杂化连接的连接连接的连接绿色合成是一种绿色合成.纳米规模的药物输送.银纳米颗粒的使用方法表面功能化的功能化.

更多相关视频

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria

Published on: October 4, 2024

相关概念视频

Combined Effects of Drugs: Synergism

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...

Hand hygiene

Hand hygiene

Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...

Colloidal precipitates

Colloidal precipitates

The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...

Antimicrobial Effectiveness

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...