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相关概念视频

Precipitation Processes01:12

Precipitation Processes

483
The experimental conditions in a gravimetric analysis should be optimized to maximize the particle size and purity of the obtained precipitate. Ideally, the concentration of the precipitating reagent should be low with effective stirring to maintain low relative supersaturation for the growth of large crystals. In homogeneous precipitation, the precipitant is slowly generated by a chemical reaction in the solution to avoid local reagent excesses. For example, urea decomposes gradually to...
483
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

147
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
147

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相关实验视频

Updated: Jul 15, 2025

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
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综合连续湿颗粒和干燥:过程评估和与批量加工进行比较.

Seth P Forster1, Erin Dippold1, Abbe Haser2

  • 1Merck & Co., Inc., West Point, PA 19486, USA.

Pharmaceutics
|September 28, 2023
PubMed
概括
此摘要是机器生成的。

药品的连续制造正在推进. 持续湿颗粒和干燥的新设备显示出有前途,生产高质量的颗粒与传统批量方法相比.

关键词:
连续干燥 不断干燥连续颗粒制造的持续颗粒化连续制造 连续制造制药公司的药品.制药制造 制药制造 制药制造 制药制造湿颗粒的湿颗粒化方法

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科学领域:

  • 制药制造业 制药制造业 制药制造业
  • 化学工程是化学工程的重要组成部分.
  • 材料科学 材料科学 材料科学

背景情况:

  • 制药行业正在从批量制造转向连续制造.
  • 由于设备的局限性,湿颗粒对连续加工带来了独特的挑战.
  • 对于连续颗粒干燥的选择有限.

研究的目的:

  • 描述新型连续湿颗粒和干燥设备的工艺空间.
  • 用这种新设备生产的颗粒与传统的批量方法进行比较.
  • 评估连续湿颗粒和干燥的有效性和质量.

主要方法:

  • 使用了试点和商业规模的设备,结合了双螺丝湿颗粒机和水平振动液床干燥器.
  • 描述了连续设备的工艺空间.
  • 通过连续和批量 (高剪切和流体床) 湿颗粒加工过程产生的颗粒性能进行比较.

主要成果:

  • 这种新型设备有效地在各种配方中进行颗粒和干燥.
  • 生产的颗粒的质量与批处理过程中的颗粒相比或更好.
  • 该设备展示了一个可行的工艺空间,用于连续的湿颗粒和干燥.

结论:

  • 开发的双螺杆颗粒器和振动流体床干燥系统对于连续湿颗粒和干燥是有效的.
  • 这项技术为传统的批量湿颗粒制造提供了可行的替代方案,生产高质量的颗粒.
  • 这些发现支持湿颗粒工艺向连续制造的过渡.