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在新生儿中预测分布体积:基于生理学上的药代动力学建模的性能

Pieter-Jan De Sutter1, Phebe Rossignol1, Lien Breëns1

  • 1Department of Bioanalysis, Ghent University, 9000 Ghent, Belgium.

Pharmaceutics
|September 28, 2023
PubMed
概括

基于生理学的药理动力学 (PBPK) 模型改善了与传统缩放相比,在新生儿中稳定状态下 (Vss) 药物分布量的预测. 波林和泰尔与贝雷赫科夫斯基校正方法的准确性比罗杰斯和罗兰更好.

关键词:
测量尺度缩放 (allometric scaling) 是指所有米尺度缩放的方法.发展性药理学 发展性药理学新生儿们的新生儿药物动力学 药物动力学基于生理学的药理动力学 (PBPK)分发的分发量.

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