基托桑在口服药物输送配方中的作用:一篇评论
Tanikan Sangnim1, Divya Dheer2,3, Nitin Jangra2
1Faculty of Pharmaceutical Sciences, Burapha University, Chonburi 20131, Thailand.
Pharmaceutics
|September 28, 2023
概括
素纳米颗粒为口服药物输送提供了一个有前途的解决方案,克服了像吸收不良和第一通代谢等常见挑战. 本次审查突出了它们通过受控释放和向输送来增强治疗功效的潜力.
科学领域:
- 制药科学 制药科学
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
背景情况:
- 口服药物管理面临诸多挑战,包括生物可用性差和胃肠道问题.
- 第一次肝过境显著影响药物的疗效.
- 可生物降解的天然聚合物,特别是酸盐,显示出改善口服药物输送系统的潜力.
研究的目的:
- 审查最近口服输送的基托桑纳米粒子干预措施的进展.
- 突出基托桑纳米颗粒在药物输送中的特性和应用.
主要方法:
- 关于口服托桑纳米颗粒的科学文献的综述.
- 对素与纳米粒子合成相关的物理化学性质的分析.
- 检查表明提高药物有效性和吸收的研究.
主要成果:
- 基托纳米颗粒显示出控制药物释放的显著潜力.
- 这些纳米粒子可以克服诸如溶解性差和第一通代谢等障碍.
- 酸盐增强了药物的封装,运输和与细胞的相互作用.
结论:
- 口服的奇托纳米颗粒代表了药物输送技术的重大进步.
- 酸盐的特性使其成为开发有效纳米配方的理想候选者.
- 对素纳米粒子干预的进一步研究有望改善治疗结果.
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