双金属-银纳米颗粒的瓜皮介导生物合成:特征,抗菌和抗癌活动
Amr H Hashem1, Gharieb S El-Sayyad2,3,4, Abdulaziz A Al-Askar5
1Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt.
Plants (Basel, Switzerland)
|September 28, 2023
概括
使用西瓜皮提取物合成双金属-银纳米粒子 (Se-Ag NPs) 的绿色合成显示出强大的抗菌和抗癌活性. 这些新的Se-AgNP提供了降低毒性和治疗应用的增强潜力.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 微生物感染构成了全球健康威胁,推动了对新型抗菌剂的研究.
- 双金属纳米粒子 (NP) 正因为它们的协同作用特性而成为对抗微生物感染的有希望的候选物.
研究的目的:
- 使用西瓜皮 (WR) 提取物通过绿色方法生物合成双金属-银纳米粒子 (Se-Ag NPs).
- 描述合成的Se-AgNP并评估它们的抗微生物,抗真菌和抗癌活性.
主要方法:
- 绿色合成Se-AgNP使用西瓜皮的提取物.
- 使用紫外线可见光谱,传输电子显微镜 (TEM) 和能量分散式X射线光谱 (EDX) 的表征.
- 对各种细菌和真菌菌株的抗微生物活性,对Wi38正常细胞的细胞毒性和对MCF7癌细胞的抗癌活性的评估.
主要成果:
- 能够成功合成Se-AgNP,其大小从18.3nm到49.6nm不等.
- 这些NP显示出对*Candida albicans*,*Escherichia coli*,*Pseudomonas aeruginosa*,*Klebsiella oxytoca*,*Bacillus subtilis*和*Staphylococcus aureus* (MIC:12.550μg/mL) 的协同抗菌活性.
- 细胞毒性评估显示,针对Wi38正常细胞的IC50为168.42μg/mL,而针对MCF7细胞的抗癌活性则产生21.6μg/mL的IC50.
结论:
- 首次使用西瓜皮提取物合成双金属Se-AgNP的绿色合成.
- 合成的Se-AgNP显示出显著的抗菌,抗真菌和抗癌特性.
- 该研究强调了Se-AgNP的潜力,作为治疗应用中银纳米颗粒的毒性较低的替代品.
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