复合骨质水泥具有增强的药物化
Kirill Cherednichenko1, Adeliya Sayfutdinova1, Denis Rimashevskiy1,2
1Department of Physical and Colloid Chemistry, Faculty of Chemical and Environmental Engineering, National University of Oil and Gas "Gubkin University", Moscow 119991, Russia.
Polymers
|September 28, 2023
概括
像纳米纤维化纤维素这样的天然添加剂可以增强用于骨科手术的抗生素加载骨质水泥 (ALBC). 这些复合材料提高了药物化和机械强度,提供了更好的感染控制和治疗选择.
科学领域:
- 骨科生物材料 骨科生物材料
- 聚合物科学 聚合物科学
- 药物输送系统 药物输送系统
背景情况:
- 带有抗生素的骨质水泥 (ALBC) 对于骨科感染的预防和治疗至关重要.
- 将抗生素添加到骨可以降低机械强度并限制药物化.
- 天然微/纳米级材料作为添加剂提供了提高ALBC性能的潜力.
研究的目的:
- 为了研究天然添加剂 (化,CNC,MFC,NFC) 对化装载骨水泥的影响.
- 评估这些添加剂对聚合特性和机械性能的影响.
- 确定最佳的添加剂,以提高药物释放和水泥性能.
主要方法:
- 使用了商用Simplex P骨水泥,预装了万科米.
- 添加了四种天然添加剂 (化体,纳米晶体纤维素,微纤维和纳米纤维化纤维素).
- 聚合 (温度,定时间,单体出),药物化和微硬度被全面研究.
主要成果:
- 与标准ALBC相比,所有天然添加剂增强了药物化和微硬度.
- 纳米纤维化纤维素 (NFC) 显示出最好的整体性能.
- NFC提高了聚合率,减少了单体漏,增加了抗生素释放和微硬度.
结论:
- 自然的微/纳米级材料可以显著提高带有抗生素的骨水泥的性能.
- 纳米纤维化纤维素是一种有前途的添加剂,用于开发具有卓越药物传递和机械完整性的先进骨.
- 这些增强的ALBC配方有可能改善骨科感染管理.
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