乘坐Omicron BA.5波:在慢性血液透析患者接种双对应的Omicron BA.4-5-Adapted mRNA SARS-CoV-2疫苗后,改善了免疫反应
Eugen Ovcar1,2,3, Sammy Patyna1, Niko Kohmer4
1Department of Internal Medicine 4, Nephrology, University Hospital, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany.
Vaccines
|September 28, 2023
概括
双价mRNA疫苗显著提高了血液透析患者对Omicron BA.5的抗体水平和中和. 这种改善的幽默免疫力减少了这种脆弱人群中严重的COVID-19结果.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 血液透析患者经历了较高的COVID-19发病率和死亡率.
- 第二代mRNA疫苗的目标是SARS-CoV-2 Omicron BA.4 / BA.5变种.
研究的目的:
- 评估双价mRNA疫苗对血液透析患者幽默免疫力的影响.
- 评估针对SARS-CoV-2变种的免疫反应,包括Omicron BA.5.5.
主要方法:
- 研究了66名先前接触过SARS-CoV-2的血液透析患者.
- 测量了抗SARS-CoV-2尖端受体结合域IgG抗体 (S-RBD-ab) 的水平.
- 疫苗接种前和后评估了对祖先,三角体,欧米克朗菌株 (SVNT) 和BA.5 (PRNT) 的中和抗体.
主要成果:
- 双对应的mRNA疫苗增加了7.6倍的S-RBD-ab和35%的Omicron抑制 (SVNT).
- 78.4%的先前阴性血清患者实现了对Omicron BA.5 (PRNT) 的血清转化.
- S-RBD-ab水平与Omicron 中和相关.
结论:
- 双对应的mRNA疫苗接种增强了血液透析患者的SARS-CoV-2变异特异性幽默免疫力.
- 在这种人群中,S-RBD-ab测量可以估计Omicron BA.5幽默免疫力.
- 在随访期间,接种疫苗导致没有危及生命的COVID-19病例.
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