在免疫抑制时代的疫苗接种
Fatima Alnaimat1, Jaleel Jerry G Sweis2, Jacqueline Jansz3
1Department of Internal Medicine, Division of Rheumatology, School of Medicine, University of Jordan, Amman 11942, Jordan.
Vaccines
|September 28, 2023
概括
患有自身免疫性炎症性类风湿病 (AIIRDs) 的患者面临更高的感染风险,可能有不同的疫苗反应. 优化疫苗接种策略对于改善他们的健康结果至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 患有自身免疫性炎症性类风湿性疾病 (AIIRDs) 的患者对严重感染的易感性增加.
- 与一般人群相比,AIIRD患者的疫苗有效性和安全性可能会受到免疫抑制药物和特定疫苗的影响而改变.
- 在这个队列中,B细胞枯竭疗法与疫苗免疫性不佳有关.
研究的目的:
- 审查AIIRD患者的疫苗反应,安全性和疗效,特别是那些接受免疫抑制治疗的患者.
- 突出低于最佳的疫苗接种率,并讨论实现充分免疫保护所面临的挑战.
- 探索未来的方向,以加强免疫抑制的AIIRD患者的疫苗策略.
主要方法:
- 文献综述和AIIRD患者疫苗接种现有证据的综合.
- 对影响疫苗免疫性因素的分析,包括药物类型和服用时间.
- 讨论对优化疫苗接种方案的临床试验需求.
主要成果:
- 虽然AIIRD患者的疫苗反应可能会减少,但它们通常在临床上是足够的.
- 疫苗接种很少引起严重的爆发;任何爆发通常都很轻微.
- 疫苗接种率仍然低于最佳水平,尽管感染风险增加.
结论:
- 改善AIIRD患者的疫苗接种策略对于减轻感染风险至关重要.
- 未来的方法可能包括定制疫苗和评估暂时停止免疫抑制剂.
- 需要进行进一步的临床试验,以为各种AIIRD人群建立最佳的疫苗接种方案.
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