在越南的蝙蝠中检测到filoviruses
Marat T Makenov1, Lan Anh T Le2, Olga A Stukolova1
1Department of Molecular Diagnostics and Epidemiology, Central Research Institute of Epidemiology, 111123 Moscow, Russia.
Viruses
|September 28, 2023
概括
包括Dianlovirus在内的filoviruses在越南的蝙蝠中被检测到,扩大了它们已知的地理范围. 这一发现强调了持续监测蝙蝠群体中新型病毒的重要性.
科学领域:
- 病毒学 病毒学
- 动物传播疾病 动物传播疾病
- 蝙蝠生态学蝙蝠生态学
背景情况:
- 2015年,一种属于新属Dianlovirus的新型filovirus,Ménglà病毒,在中国的蝙蝠中被发现.
- 众所周知,菲洛病毒会导致人类严重的出血发烧,因此需要对新的病毒威胁进行监测.
- 菲洛病毒的地理分布和宿主范围尚未完全理解.
研究的目的:
- 为了调查越南蝙蝠种群中filoviruses的存在.
- 通过遗传学分析来表征任何检测到的filoviruses.
- 评估越南蝙蝠中抗马尔堡病毒抗体的血清流行率.
主要方法:
- 在越南不同省份,采集了来自15个物种的248只蝙蝠样本.
- 使用分子方法检测菲洛病毒RNA.
- 聚合酶基因片段的遗传学分析用于病毒分类.
- 与酶相关的免疫吸收试验 (ELISA) 检测对马尔堡病毒糖蛋白的抗体.
主要成果:
- 在五种蝙蝠中检测到filovirusRNA:四种来自Lai Chau省的Rousettus leschenaultii和一个来自Rousettus amplexicaudatus.
- 遗传学分析表明,三个阳性样本属于Dianlovirus,而两个则在Orthomarburgvirus附近形成了一个独特的分类.
- 对马尔堡病毒糖蛋白的抗体在9%的Rousettus,13%的Eonycteris和10%的Cynopterus蝙蝠中被发现.
结论:
- 这项研究报告了在越南蝙蝠中首次检测到包括Dianlovirus在内的filoviruses,扩大了它们已知的地理分布.
- 这些发现表明,越南蝙蝠种群中存在多种不同的filovirus血统,其中一些与已知的致病性属有关.
- 血清学结果表明越南蝙蝠的交叉反应性或先前暴露于马尔堡病毒类病原体,需要进一步调查.
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