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一种新型的禽类复原病毒对接种疫苗的具有病原性

Rui Liu¹, Dan Luo¹, Jinhui Gao¹

¹Division of Avian Immunosuppressive Diseases, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.

|September 28, 2023

概括

在接种疫苗的中发现了一种新的禽类转录病毒 (ARV) 变体ARV-SD19/11103. 这种变异与目前的疫苗具有显著的遗传和抗原差异,导致疾病,并强调需要更新的ARV疫苗.

科学领域:

兽医病毒学兽医病毒学
免疫学免疫学免疫学
禽类的健康禽类的健康

背景情况:

禽类转录病毒 (ARV) 感染导致家禽因关节炎和免疫抑制而造成重大经济损失.
现有的ARV疫苗未能预防中国一些商业家禽群的感染.

研究的目的:

隔离和描述一种新型ARV变种,该变种负责疫苗突破性感染.
分析新ARV变种的遗传和抗原性质.

主要方法:

从受感染的肉中分离了ARV-SD19/11103.
对ARV σC基因的基因分析,包括与疫苗菌株的氨基酸序列比较.
在特定无病原体的胚胎和小中进行致病性评估.
交叉中和试验用于评估抗原差异.

主要成果:

一种新的ARV变种ARV-SD19/11103从接种疫苗的肉中分离出来.
这种变体与常见的疫苗菌株 (S1133,1733,2408) 具有<80%的氨基酸相似性,在σC蛋白中有33种氨基酸差异.
ARV-SD19/11103在中表现出致病性,包括那些用商业ARV疫苗接种疫苗的.
交叉中和试验显示,与基因型集群I的ARV菌株存在显著的抗原分歧.

结论:

已识别的ARV变种具有独特的遗传和抗原特征,使其与当前的疫苗菌株有所区别.
这种新型变种可以在接种疫苗的家禽中引起疾病,这表明疫苗逃逸.
这些发现强调了开发新型ARV疫苗的必要性,以应对流通的变种并改善家禽的保护.

关键词:

鸟类的复原病毒.免疫接种的小.病原性病原性病原性变种变种变种变种变种

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