增加的神经炎症与艾滋病毒感染者的神经退行性增加有关
Azin Tavasoli1, Benjamin B Gelman2, Christina M Marra3
1Department of Neurosciences, University of California San Diego, San Diego, CA 92093, USA.
Viruses
|September 28, 2023
概括
艾滋病毒感染导致神经炎症和全身炎症,导致艾滋病毒 (PWH) 感染者的神经退行. 纵向数据显示,炎症标志物增加与神经退行恶化相关,这表明减少炎症可能有所帮助.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 艾滋病毒感染诱导神经炎症和免疫激活 (NIIA) 和全身炎症和免疫激活 (SIIA).
- 这些炎症过程与艾滋病毒 (PWH) 感染者的神经退行 (ND) 有关.
- 以前的横截面研究表明,NIIA和ND生物标志物之间存在相关性.
研究的目的:
- 纵向评估PWH中NIIA,SIIA和ND之间的关系.
- 为了确定炎症标志物是否会随着时间的推移预测未来的神经退行.
主要方法:
- 在PWH脑脊液 (CSF) 和血中对NIIA,SIIA和ND的14个生物标志物的纵向分析.
- 在CHARTER老龄化项目中,在基线和12年后收集的数据.
- 用于创建NIIA,SIIA和ND的简化指数的因素分析.
主要成果:
- 一个特定的NIIA指数 (因子1) 与中枢神经神经丝光链 (NFL) 的增加相关,这是神经退行症的标志物 (r = 0.370,p = 0.0002).
- 这项研究确定了关键的炎症和神经退行性生物标志物,包括sTNFR-II,神经病原蛋白,MCP1,IL-6,CRP,D-二分体,p-tau,Aβ42和NFL.
- 因子分析揭示了不同的炎症和神经退行模式.
结论:
- 在NIIA和SIIA的增加与PWH的ND的增加长度相关.
- 这些发现支持了减少神经炎症和全身炎症可能会减缓或逆转神经退行症的假设.
- 针对炎症是一种潜在的治疗策略,用于管理与艾滋病毒相关的神经退行.
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