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人类免疫缺陷病毒感染者接种疫苗的免疫性和有效性

Eeva Tortellini¹, Yann Collins Fosso Ngangue¹, Federica Dominelli¹

¹Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.

|September 28, 2023

概括

艾滋病毒感染者 (PLWH) 对疫苗的免疫反应受损,增加了他们患可预防疾病的风险. 了解艾滋病毒和其他疾病如何影响疫苗疗效对于优化免疫策略至关重要.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

艾滋病毒感染者 (PLWH) 经历了疫苗可预防疾病的死亡率和发病率增加,尽管抗逆转录病毒疗法 (ART) 取得了进展.
关键的临床问题涉及PLWH整个生命周期的最佳时机,类型和疫苗剂量.
对疫苗的免疫反应通常在PLWH中减少,尽管ART和增加的CD4+T细胞数量可以改善疫苗反应.

研究的目的:

在艾滋病毒感染的背景下全面审查有关疫苗免疫反应的现有文献.
强调艾滋病毒特异性因素,并发病和共感染如何调节这些免疫反应.
为未来的PLWH疫苗接种和预防策略提供信息.

主要方法:

关于研究艾滋病毒感染者对各种疫苗的免疫反应的文献综述.
分析影响疫苗疗效的因素,包括病毒载荷控制,CD4+T细胞计数,并发症和并发感染.
综合发现,提供对当前知识状况的全面概述.

主要成果:

在PLWH中,对大多数疫苗的免疫反应受到损害.
ART和恢复的CD4+T细胞计数与改善的疫苗反应相关.
免疫变化,并发症和并发感染可以显著改变PLWH的疫苗反应.

结论:

更深入地了解PLWH中疫苗免疫性是必不可少的.
与艾滋病毒相关的因素和并发症极大地影响了疫苗反应调节.
这些知识对于制定有效的疫苗接种指南和PLWH预防策略至关重要.

关键词:

艺术艺术艺术艺术 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD7 CD7 CD7 CD7 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD8 CD9 CD8 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 CD9 在 COVID-19 疫情中,艾滋病病毒艾滋病病毒艾滋病病毒这是一个HPVHPVHPV.PLWHWH是什么意思免疫反应的免疫反应.流感流感流感流感流感接种疫苗接种疫苗

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