经典和重组块性皮肤疾病病毒之间的粗病理比较
Irina Shumilova1, Alexander Sprygin1, Ali Mazloum1
1Federal Center for Animal Health, 600901 Vladimir, Russia.
Viruses
|September 28, 2023
概括
这项研究比较了牛中的块性皮肤病病毒 (LSDV) 菌株. 复合疫苗样菌株Udmurtiya/2019比古典菌株显示出更严重的皮肤和淋巴结病理.
科学领域:
- 兽医病理学 兽医病理学
- 病毒学 病毒学
- 动物健康 动物健康
背景情况:
- 型皮肤病 (LSD) 是全球牛的重大威胁.
- 了解不同块性皮肤病病毒 (LSDV) 菌株的比较病理对于疾病管理和疫苗开发至关重要.
- 以前的研究已经确定了各种LSDV集群,但直接的病理比较是有限的.
研究的目的:
- 在实验感染牛群中比较分析三种不同的LSDV菌株引起的总病理变化.
- 评估经典野外菌株 (达吉斯坦/2015),复合疫苗样菌株 (萨拉托夫/2017) 和另一个集群2.2菌株 (乌德穆尔蒂亚/2019) 的致病性.
- 为未来对新型LSDV菌株进行比较研究建立实验验证的基础.
主要方法:
- 通过静脉注射标准剂量 (10^5 TCID50/mL) 的三种LSDV分离物,对牛进行实验性感染.
- 感染后详细检查皮肤,淋巴结,气管和肺部的病理检查.
- 组织病理学评估,以确定组织亡和二次炎症过程.
主要成果:
- 所有测试的LSDV菌株 (达吉斯坦/2015,萨拉托夫/2017,乌德穆尔蒂亚/2019) 都具有毒性,并导致皮肤,淋巴结,气管和肺部的病理变化.
- 与古典菌株相比,复合疫苗样菌株Udmurtiya/2019表现出更明显的病理解剖图像.
- 特定的淋巴结病理 (血清性炎症,焦点性淋巴腺炎) 观察到达吉斯坦/2015和乌德穆尔蒂亚/2019,但不是萨拉托夫/2017.
结论:
- 独特的LSDV菌株,包括古典和重组形式,诱导牛的重大病理变化.
- 复合疫苗样菌株Udmurtiya/2019显示出比研究的古典菌株更严重的病理表现.
- 在淋巴结病理学中观察到的差异强调了需要仔细评估LSDV菌株毒性和疫苗疗效的需要.
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