与SARS-CoV-2野生型变体和令人担忧的变体相关的胎盘感染
Ana Medel-Martinez1,2, Cristina Paules1,2,3,4, María Peran1,2,5
1Instituto de Investigación Sanitario de Aragón (IIS Aragon), 50009 Zaragoza, Spain.
Viruses
|September 28, 2023
概括
SARS-CoV-2 胎盘感染仅在怀孕时检测到原始野生型病毒,而不是以后的变种引起关注. 这表明SARS-CoV-2变种,感染时间和疫苗接种状态都会影响胎盘病毒的存在,因此需要对孕妇进行最新的风险评估.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 引起关注的SARS-CoV-2变种 (VOCs) 的出现改变了COVID-19的格局.
- 了解不同SARS-CoV-2血统的胎盘感染动态对于母亲和胎儿的健康至关重要.
研究的目的:
- 根据诊断时占主导地位的病毒变异来评估孕妇的胎盘SARS-CoV-2感染.
- 为了比较前的VOC和VOC感染期间之间的胎盘感染和不良妊娠结果的发病率.
主要方法:
- 在2020年3月至2022年3月期间,对104名SARS-CoV-2阳性孕妇进行前性研究.
- 胎盘样本通过RT-PCR分析SARS-CoV-2的存在和全基因组测序来识别变体.
- 参与者分为前VOC (2020) 和VOC (2020年12月后) 组.
主要成果:
- 在前-VOC组的29.6%的胎盘组织中检测到SARS-CoV-2,但在VOC组的0% (p=0.000).
- 早产 (16.7%与4%) 和妊娠高血压障碍 (25.9%与6%) 在Pre-VOC组中明显更频繁.
- 根据VOC组内疫苗接种状况,没有观察到结果的显著差异.
结论:
- 胎盘SARS-CoV-2感染仅与野生型病毒观察到,而不是VOCs.
- 胎盘中SARS-CoV-2的存在似乎受到病毒变异,感染时间和潜在的疫苗接种状态的影响.
- 目前对孕妇SARS-CoV-2胎盘感染的风险评估需要根据这些发现进行更新.
相关概念视频
Viral Recombination
23.5K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.5K
Single Nucleotide Polymorphisms-SNPs
15.2K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.2K
Factors Affecting the Risk of Infection
11.9K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.9K
Pneumonia II: Pathophysiology
314
The pathophysiology of pneumonia involves the following steps:
314
Pneumonia III: Complications and Assessment
253
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
253
Endocarditis II: Clinical Features of Infective Endocarditis
13
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
13


