基于COVID-19患者的完整血液计数的炎症生物标志物的预后性能
Thilo Gambichler1,2, Nadine Schuleit1, Laura Susok1,3
1Department of Dermatology, Ruhr-University, 44791 Bochum, Germany.
Viruses
|September 28, 2023
概括
中性粒细胞与淋巴细胞的比率 (NLR) 和绝对乙素细胞计数 (AEC) 是预测COVID-19严重程度和死亡率的有效生物标志物. 特别是AEC,作为患者结果的可访问指标,显示出前景.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 临床病理学 临床病理学
背景情况:
- COVID-19已经过渡到一个具有季节性爆发潜力的特有阶段.
- 可访问的预后生物标志物对于管理COVID-19患者至关重要.
- 之前的研究探索了COVID-19预后的各种炎症标志物.
研究的目的:
- 评估COVID-19患者临床和血液生物标志物的预后性能.
- 为了比较中性粒细胞与淋巴细胞比率 (NLR),系统性免疫炎症指数 (SII),泛免疫炎症值 (PIV) 和绝对乙氨 (AEP) 在预测COVID-19结果方面的有效性.
- 为了确定可访问的生物标志物来评估COVID-19的严重程度和死亡率.
主要方法:
- 一个单一的研究涉及412名COVID-19患者在德国第三级护理医院.
- 对NLR,SII,PIV和AEP的评估 (绝对乙酸细胞计数为0/μL).
- 利用Siddiqui和Mehra阶段,世卫组织临床进展量表和COVID-19相关死亡作为结果措施.
主要成果:
- 年龄>75岁,高C反应蛋白 (CRP),AEP,心血管并发症和高费里预测了严重的COVID-19 (Siddiqui和Mehra阶段).
- 年龄>75岁,高CRP,高乳酸脱酶 (LDH),AEP和高NLR预测了严重的COVID-19 (世界卫生组织规模).
- 年龄>75岁,高LDH,高NLR和AEP独立预测了COVID-19相关死亡. 在74.5%的患者中存在欧素 (<40/μL),近45%的患者有AEP.
结论:
- 中性粒细胞与淋巴细胞的比率 (NLR) 与更复杂的生物标志物 (如SII和PIV) 相比,在COVID-19中表现出优异的预后性能.
- 降低乙氨基酸细胞数量是COVID-19感染的潜在标志.
- 绝对乙酸细胞计数 (AEC) 是一个可访问和独立的生物标志物,用于预测COVID-19的严重程度和死亡率.
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