适应性 流感A病毒的决定因素 病毒
Emily Fate Griffin1,2,3, Stephen Mark Tompkins1,2,3,4
1Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Viruses
|September 28, 2023
概括
A型流感病毒 (IAV) 构成了全球健康威胁. 本综述研究了猪IAV和2009年流行病菌株的遗传因素,这些因素影响了适应,传播和毒性.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 流感A型病毒 (IAV) 是一个重要的全球呼吸道病原体,每年导致疾病,住院和死亡.
- IAV的动物性和广泛的宿主范围促进了物种间的传播和重组,导致了新的流行病,例如2009年猪源H1N1 (pdmH1N1) 流行病.
- pdmH1N1病毒及其基因段与人类和动物模型中疾病严重程度的增加有关,猪体中循环的遗传成分继续构成风险.
研究的目的:
- 审查目前对影响特定IAV表型的遗传决定因素的理解.
- 专注于在猪IAV和2009年pdmH1N1病毒中发现的适应性,传播和毒性决定因素.
- 提高对流感病毒生物学的理解,帮助监测,风险评估和对策开发.
主要方法:
- 对IAV遗传学现有研究的文献综述,重点是猪分离物和2009年pdmH1N1病毒.
- 分析与物种适应,毒性和跨物种传播相关的遗传变化.
- 综合与病毒适应性和传播决定因素相关的发现.
主要成果:
- 猪群中pdmH1N1病毒的遗传组件持续存在,与特有病毒重新组合,偶尔会蔓延到人类.
- 常常在人类中检测到猪IAV的变体,特别是在人猪相互作用的环境中.
- 已经确定了影响IAV适应性,传播和毒性的特定遗传变化.
结论:
- 了解IAV表型的遗传决定因素对于预测病毒进化和出现至关重要.
- 持续监测猪IAV和基因分析对于评估与动物传播相关的风险至关重要.
- 了解这些决定因素将指导开发有效的策略来控制流感大流行.
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