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血糖控制和B组链球菌在怀孕期间糖尿病的孕妇中殖民之间的关联
Christine Field1, T Caroline Bank1, Colleen K Spees2
1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio, USA.
怀孕期糖尿病和血糖控制不良的孕妇面临B组链球菌 (GBS) 殖民的更高风险. 保持更好的血糖控制可以降低这种风险.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
背景情况:
- 孕期糖尿病 (PDM) 是一个已知的妊娠不良结果的危险因素.
- 在怀孕期间B组链球菌 (GBS) 殖民可能导致严重的新生儿感染.
- 血糖控制对PDM怀孕中GBS殖民风险的影响尚不清楚.
研究的目的:
- 为了研究血糖控制之间的关系,通过血红蛋白A1c (A1c) 测量,在怀孕的个人与PDMGBS殖民.
- 确定特定的A1c值是否与GBS殖民的不同风险相关.
主要方法:
- 在第三级护理中心对305名患有PDM的孕妇进行了回顾性队列研究.
- 血糖控制通过20周妊娠时的血红蛋白A1c (A1c) 水平进行评估,分类为<6.5%和<6.0%,并作为连续变量.
- 作为主要结果的母体GBS殖民化,使用调整为共变量的多变量逻辑回归来分析.
主要成果:
- 45%的参与者被GBS殖民.
- 较低的A1c水平 (<6.5%和<6.0%) 与GBS殖民的可能性显著降低有关 (AOR分别为0.55和0.60).
- 连续A1c每增加1%都与GBS殖民的几率增加57%有关 (AOR 1.57).
结论:
- 孕妇患有PDM的孕妇的血糖控制较差与GBS殖民的风险增加有关.
- 这些发现表明,优化血糖控制可能是减轻GBS殖民风险的策略.
- 需要进一步的研究来确认因果关系并探索干预措施.
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