单细胞多基因组测序揭示了在螺旋转移后重组的人类胚胎中,肌体和细胞内质量之间的染色体复制数不一致

Wei Zhong1,2, Kexin Shen1,2, Xiaohui Xue3

  • 1School of Medicine, South China University of Technology, Guangzhou, China.

PubMed
概括

来自螺旋转移 (ST) 胚胎的托菲克托德姆 (TE) 活检不能准确地表示细胞内部质量 (ICM) 染色体复制号. 这一发现表明,与传统的ICSI胚胎相比,ST胚胎的前植入基因检测 (PGT-A) 可能对ST胚胎的可靠性较低.

相关概念视频

Crossing Over01:34

Crossing Over

Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
147.1K
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
5.2K
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
1.8K