慢性病患者的酸盐和冠状动脉疾病
Hiroaki Ogata1,2, Hirohito Sugawara1, Masahiro Yamamoto1
1Division of Nephrology, Department of Internal Medicine, Showa University Northern Yokohama Hospital.
Journal of atherosclerosis and thrombosis
|September 28, 2023
概括
慢性病 (CKD) 患者的高酸盐水平显著增加了心血管疾病 (CVD) 风险. 本综述详细介绍了酸盐如何通过动脉化和心脏重塑影响冠状动脉疾病.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 生物化学 生物化学
背景情况:
- 心血管疾病 (CVD) 是慢性病 (CKD) 患者的主要死亡原因.
- 传统因素和CKD特异性因素都对这一群体的心血管疾病风险有所贡献.
- 慢性瘤 - 矿物质和骨疾病是晚期慢性瘤中非动脉样硬化心血管疾病的关键因素.
研究的目的:
- 在CKD患者中审查酸盐水平升高与冠状动脉疾病 (CAD) 之间的关联.
- 阐明酸盐有助于CKD中心血管疾病的发病机制.
- 突出高酸血症在动脉化和心脏重塑中的作用.
主要方法:
- 对研究酸盐含量,心血管疾病和慢性脑血管疾病的文献综述.
- 分析将酸盐与动脉样硬化和非动脉样硬化心血管疾病联系起来的病理生理机制.
- 综合证据对高酸盐血症对血管光滑肌细胞,心脏细胞和脂质代谢的影响.
主要成果:
- 较高的血清酸盐与心血管事件和CKD和非CKD患者的死亡率有显著联系.
- 增加的酸盐负载促进动脉中间化和左心室缩,增加CAD风险.
- 过酸血症有助于心肌细胞缩,心脏纤维化,并可能通过新的胆固醇合成对他类药物产生抗性.
结论:
- 升高的酸盐负载是冠状动脉疾病在CKD患者的发展和进展的关键因素.
- 酸盐诱导的动脉化,心脏重塑和改变的脂质代谢强调了其有害的心血管影响.
- 了解这些机制对于管理CKD中心血管疾病风险至关重要.
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